Investigating the
mechanisms of spread of leprosy (leprosy) in the body, scientists have noticed
that its agents - bacteria Mycobacterium lepta - can exchange mature cells into
stem cells (which can develop into different cell types).
Researchers have
identified lemmotsity mice and infected them with agents of leprosy.
Bacteria
"reprogrammed" cells by revolving off genes associated with the
mature state of Schwann cells, and the activation of genes involved in the
regulation of embryonic development and the state.
Healthy lemmotsity able
to go into an immature state, and then change into other types of cells to help
repair damaged nerve tissue. Mycobacterium lepta have paid the property in its
favor, "reprogrammed" Schwann cells are able to migrate through the
body and pass the "saddle" of bacteria. Once infected cells reach,
such as skeletal muscle, they are adjacent to the cells of this tissue,
spreading infection.
Separating proteins
chemokines , infected stem cells attract immune cells, which may also end up as
a vehicle for pathogens leprosy.
The mechanism of
"reprogramming" of cells by bacteria is not yet clear, but the
experiment will discover how leprosy spread from end to end the body. Perhaps
this knowledge will help to stop the disease in its early stages. Also,
scientists hope to use bacteria to convert adult cells into stem cells in the
laboratory to search for regenerative therapies for diseases such as diabetes
and Alzheimer's disease.
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